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SeqDesk · original analysis

Phylogenetics & alignment tool trends

Citation adoption for curated phylogenetics & alignment tools, counted weekly from OpenAlex.

MAFFT 7
most-cited · 48K citations
6
tools tracked
1
selected group
20042025
citation years
View
Y axis
01101001.0K20042007201020132016201920222025citing-paper year · annual citations · log y-axisMAFFT 7 · 6.0K citations in 2025 · peak 6.0K/yr in 2025 · 48K lifetimeMUSCLE · 2.7K citations in 2025 · peak 3.8K/yr in 2020 · 47K lifetimeRAxML · 2.6K citations in 2025 · peak 4.3K/yr in 2020 · 34K lifetimeIQ-TREE 2 · 4.6K citations in 2025 · peak 4.6K/yr in 2025 · 17K lifetimeFastTree 2 · 1.7K citations in 2025 · peak 1.7K/yr in 2021 · 16K lifetimetrimAl · 2.2K citations in 2025 · peak 2.2K/yr in 2025 · 14K lifetimeMAFFT 7IQ-TREE 2MUSCLERAxMLtrimAlFastTree 2
Hover a line, or focus a legend item, to see exact citation values. Click legend items to hide or show tools.
RAxML
348
IQ-TREE 2
333
MUSCLE
284
trimAl
263
FastTree 2
39
MAFFT 7
web
trimAl
active · this month
FastTree 2
active · 2 mo ago
MUSCLE
active · 2 mo ago
IQ-TREE 2
active · 4 mo ago
RAxML
active · 1.3 yr ago
MAFFT 7
unknown

Software health, not citations: GitHub/GitLab stars and last-commit date for each tool’s canonical source repo, as a point-in-time snapshot (2026-06-30). Bars in the last-commit chart show how recently each repo was touched — active, stale, archived or gone. Star bars are tinted to match each tool’s citation line above.

Use cumulative view for long-run adoption and annual view for citation momentum; log scale makes smaller tools readable without changing the counts. Counts are annual OpenAlex cited-by tallies and reflect all uses of each paper, not only use inside the selected workflow; broad tools can therefore look larger than workflow-specific methods. The still-filling current year (2026) is omitted from the lines.

10301003001.0K3.0K013612183672120169updated within 18 moIQ-TREE 2 · phylogenetics · 4.6K citations in 2025 · actively maintainedRAxML · phylogenetics · 2.6K citations in 2025 · actively maintainedFastTree 2 · phylogenetics · 1.7K citations in 2025 · actively maintainedMUSCLE · phylogenetics · 2.7K citations in 2025 · actively maintainedtrimAl · phylogenetics · 2.2K citations in 2025 · actively maintainedIQ-TREE 2months since last update (√ scale) · 2025 citations (log scale)maintainedother

Each dot is one of 5 curated tools with a datable code repository (1 web-only / SourceForge tools without a public commit date aren't shown). Higher means more cited in 2025, the latest complete year (log scale); further left means more recently updated (square-root scale). Filled dots are actively maintained — a commit within the last 18 months. The upper-left gathers the field's well-kept, widely-used staples: fastp, SAMtools, DADA2, SPAdes, Prokka, DIAMOND and more, updated regularly and cited thousands of times a year. Maintenance and citations are only loosely linked (Spearman ρ ≈ −0.46): a citation counts every paper that mentions a method, so a quieter commit history does not mean a tool is unused or unmaintained — many stable, widely-relied-on tools rarely need new commits, and development sometimes moves to mirrors this snapshot can't see. Source: OpenAlex citation graph + GitHub/GitLab activity, as of 2026-06-25.

MUSCLE
’04–’25

The leading phylogenetics & alignment tool is recomputed for each complete calendar year by cumulative citations — a 1-way hand-off across 22 years.

Cohort6 curated phylogenetics & alignment tools
MetricCitations to each tool’s canonical method paper, counted by the citing paper’s publication year
MeasurementAnnual cited-by counts from OpenAlex (cites: grouped by year when available; counts_by_year fallback when the grouped endpoint is budget-limited)
Update cadenceWeekly automated re-count · latest snapshot 2026-06-25
Scope caveatCitation totals span every field that cites the paper, not only use inside the selected workflow — read them as overall reach
Recent-year caveatThe current year (2026) is still accruing citations, so it is dropped from the trend lines
Methodscripts/check-tool-trends.mjs
ToolGroupLifetime citationsPeak yearSourceStarsLast commitStatus
MAFFT 7Phylogenetics & alignment48,2792025 (6.0K/yr)webstale
MUSCLEPhylogenetics & alignment46,5252020 (3.8K/yr)GitHub2842 mo agoactive
RAxMLPhylogenetics & alignment34,2992020 (4.3K/yr)GitHub3481.3 yr agoactive
IQ-TREE 2Phylogenetics & alignment16,7472025 (4.6K/yr)GitHub3334 mo agoactive
FastTree 2Phylogenetics & alignment15,9592021 (1.7K/yr)GitHub392 mo agoactive
trimAlPhylogenetics & alignment13,5832025 (2.2K/yr)GitHub263this monthactive

A curated cohort of phylogenetics & alignment tools, each tracked by the full citation history of its method paper — re-counted weekly straight from the OpenAlex citation graph. Only the published method papers and their public citation counts are used. · show all tool groups · back to all research data

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