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Sequencing technology

Cost per gigabase of sequence

NHGRI — DNA Sequencing Costs (Genome Sequencing Program)

$5.80
per Gb · 2022
656355K5.3M2001200520092013201720211
Timeline — what shaped the curve
  • 12008-012nd-gen sequencing — Massively parallel short-read platforms collapsed the cost of raw sequence by orders of magnitude from 2008, the steepest part of this curve.

The raw-sequence view of the same NHGRI data: cost per gigabase (1 Gb = 1,000 Mb) of DNA sequence, from ~$5.3M/Gb in 2001 to ~$5.80/Gb in 2022 (NHGRI publishes this as cost per megabase; shown here per Gb so every point stays above the chart's log floor). This decoupled from cost-per-genome as coverage standards and read counts rose, and is the better measure of pure sequencing-output economics. Not forecast.

SourceNHGRI — DNA Sequencing Costs (Genome Sequencing Program)
Update cadencerelease · manual
Live endpoint
Parsemanual
DateUSD per Gb
2022-05-315.8
2021-02-289.5
2020-02-287.2
2019-02-2811
2018-02-2813.7
2017-02-2811.3
2016-05-3113.1
2015-01-3144.1
2014-01-3144.5
2013-01-3163
2012-01-3185.2
2011-01-31233
2010-01-31520
2009-01-312,586
2008-01-31102,127
2007-01-31522,708
2006-01-31699,203
2005-01-31974,165
2004-01-311,598,910
2003-03-312,986,205
2002-03-313,898,635
2001-09-305,292,393

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